ADJUVANTS IN REGIONAL ANAESTHESIA

Many different receptors, ion channels, are involved in the pathophysiology of pain, which can serve as targets for adjuvant drugs. Despite advent long-acting local anesthetics, improvement their pharmacokinetics, and advanced regional anesthesia techniques, they do not fully meet need treatment especially chronic pain. In parallel with increase anesthetic power risk systemic toxicity increases. All this justifies use adjuvants anesthesia, is quite logical from point view multimodal analgesia. article authors present a review current literature data on anesthesia. The mechanisms action, doses, ways administration drugs described.